| Tournament details | |
|---|---|
| Dates | 20 August 1980 – 13 May 1981 | 
| Teams | 34 | 
| Final positions | |
| Champions | |
| Runners-up | |
| Tournament statistics | |
| Matches played | 65 | 
| Goals scored | 176 (2.71 per match) | 
| Top scorer(s) | David Cross (West Ham United) 6 goals  | 
The 1980–81 season of the European Cup Winners' Cup was won by Dinamo Tbilisi in the final against Carl Zeiss Jena. Dinamo Tbilisi's side defeated English Second Division side West Ham United away before beating Carl Zeiss Jena in a final watched by 4,750 people in Düsseldorf. This win was the high point of the Georgian side and is still the club's greatest achievement.
The competition included the Real Madrid reserve team, Castilla CF, who qualified as the runners-up of the 1979–80 Copa del Rey.
Preliminary round
| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg | 
|---|---|---|---|---|
| Celtic  | 
7–2 | 6–0 | 1–2 | |
| Altay  | 
0–4 | 0–0 | 0–4 | 
First leg
Second leg
Celtic won 7–2 on aggregate.
Benfica won 4–0 on aggregate.
First round
| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg | 
|---|---|---|---|---|
| Castilla CF  | 
4–6 | 3–1 | 1–5 (aet) | |
| Celtic  | 
2–2 (a) | 2–1 | 0–1 | |
| Hibernians  | 
1–4 | 1–0 | 0–4 | |
| Kastoria  | 
0–2 | 0–0 | 0–2 | |
| Spora Luxembourg  | 
0–12 | 0–6 | 0–6 | |
| Slavia Sofia  | 
3–2 | 3–1 | 0–1 | |
| Hvidovre  | 
3–0 | 1–0 | 2–0 | |
| Ilves  | 
3–7 | 1–3 | 2–4 | |
| Roma  | 
3–4 | 3–0 | 0–4 | |
| Valencia  | 
5–3 | 2–0 | 3–3 | |
| Sion  | 
1–3 | 1–1 | 0–2 | |
| Newport County  | 
4–0 | 4–0 | 0–0 | |
| Omonia  | 
1–7 | 1–3 | 0–4 | |
| Fortuna Düsseldorf  | 
8–0 | 5–0 | 3–0 | |
| Malmö  | 
1–0 | 1–0 | 0–0 | |
| Dinamo Zagreb  | 
0–2 | 0–0 | 0–2 | 
First leg
| Celtic  | 2–1 | |
|---|---|---|
| Nicholas  | 
Report | Manea  | 
| Kastoria  | 0–0 | |
|---|---|---|
| Omonia  | 1–3 | |
|---|---|---|
| Kanaris  | 
Report | Van Poucke  R. Janssen Patikkis  | 
Second leg
| Politehnica Timișoara  | 1–0 | |
|---|---|---|
| Păltinișanu  | 
Report | 
2–2 on aggregate; Politehnica Timișoara won on away goals.
| Carl Zeiss Jena  | 4–0 | |
|---|---|---|
| Krause  Lindemann Bielau  | 
Carl Zeiss Jena won 4–3 on aggregate.
| Dinamo Tbilisi  | 2–0 | |
|---|---|---|
| Shengelia  Gutsaev  | 
| Waterschei Thor  | 4–0 | |
|---|---|---|
| R. Janssen  Plessers Van Poucke  | 
Report | 
Waterschei Thor won 7–1 on aggregate.
| Benfica  | 2–0 | |
|---|---|---|
| Nené  César  | 
Report | 
Benfica won 2–0 on aggregate.
Second round
| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg | 
|---|---|---|---|---|
| West Ham United  | 
4–1 | 4–0 | 0–1 | |
| Waterford  | 
0–5 | 0–1 | 0–4 | |
| Sparta Prague  | 
2–3 | 2–0 | 0–3 | |
| Hvidovre  | 
1–3 | 1–2 | 0–1 | |
| Carl Zeiss Jena  | 
3–2 | 3–1 | 0–1 | |
| Haugar  | 
0–6 | 0–0 | 0–6 | |
| Waterschei Thor  | 
0–1 | 0–0 | 0–1 | |
| Malmö  | 
1–2 | 1–0 | 0–2 | 
First leg
| Waterford  | 0–1 | |
|---|---|---|
| Shengelia  | 
| Sparta Prague  | 2–0 | |
|---|---|---|
| Vdovjak  | 
| Hvidovre  | 1–2 | |
|---|---|---|
| Manniche  | 
Wijnstekers  Bouwens  | 
| Carl Zeiss Jena  | 3–1 | |
|---|---|---|
| Sengewald  Schnuphase Trocha  | 
Morena  | 
| Haugar  | 0–0 | |
|---|---|---|
Second leg
Newport County won 6–0 on aggregate.
West Ham United won 4–1 on aggregate.
| Dinamo Tbilisi  | 4–0 | |
|---|---|---|
| Daraselia  Chivadze Chilaia  | 
| Slavia Sofia  | 3–0 | |
|---|---|---|
| Velichkov  Zhelyazkov Tsvetkov  | 
Feyenoord won 3–1 on aggregate.
| Valencia  | 1–0 | |
|---|---|---|
| Botubot  | 
Carl Zeiss Jena won 3–2 on aggregate.
| Fortuna Düsseldorf  | 1–0 | |
|---|---|---|
| Bansemer  | 
Benfica won 2–1 on aggregate.
Quarter-finals
| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg | 
|---|---|---|---|---|
| West Ham United  | 
2–4 | 1–4 | 1–0 | |
| Slavia Sofia  | 
3–6 | 3–2 | 0–4 | |
| Carl Zeiss Jena  | 
3–2 | 2–2 | 1–0 | |
| Fortuna Düsseldorf  | 
2–3 | 2–2 | 0–1 | 
First leg
| West Ham United  | 1–4 | |
|---|---|---|
| Cross  | 
Chivadze  Gutsaev Shengelia  | 
| Carl Zeiss Jena  | 2–2 | |
|---|---|---|
| Raab  | 
Tynan  | 
| Fortuna Düsseldorf  | 2–2 | |
|---|---|---|
| Wenzel  Dusend  | 
Carlos Manuel  Coelho  | 
Second leg
| Dinamo Tbilisi  | 0–1 | |
|---|---|---|
| Pearson  | 
Dinamo Tbilisi won 4–2 on aggregate.
| Feyenoord  | 4–0 | |
|---|---|---|
| Notten  Van Deinsen Vermeulen  | 
Feyenoord won 6–3 on aggregate.
| Newport County  | 0–1 | |
|---|---|---|
| Kurbjuweit  | 
Carl Zeiss Jena won 3–2 on aggregate.
| Benfica  | 1–0 | |
|---|---|---|
| Chalana  | 
Benfica won 3–2 on aggregate.
Semi-finals
| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg | 
|---|---|---|---|---|
| Dinamo Tbilisi  | 
3–2 | 3–0 | 0–2 | |
| Carl Zeiss Jena  | 
2–1 | 2–0 | 0–1 | 
First leg
| Dinamo Tbilisi  | 3–0 | |
|---|---|---|
| Sulakvelidze  Gutsaev  | 
| Carl Zeiss Jena  | 2–0 | |
|---|---|---|
| Bielau  Raab  | 
Second leg
| Feyenoord  | 2–0 | |
|---|---|---|
| Bouwens  Notten  | 
Dinamo Tbilisi won 3–2 on aggregate.
| Benfica  | 1–0 | |
|---|---|---|
| Reinaldo  | 
Carl Zeiss Jena won 2–1 on aggregate.
Final
| Dinamo Tbilisi  | 2–1 | |
|---|---|---|
| Gutsaev  Daraselia  | 
(Report)  (Report 2)  | 
Hoppe  |