Afanasy (Russian: Афана́сий) is the Russian form of Athanasios, a Greek name meaning "immortal". It may refer to:
People:
- Afanasy Bagration, Prince Adarnase of Kartli (1707–1784), Georgian prince royal and Russian Empire general
 - Afanasy Beloborodov (1903–1990), Russian general
 - Afanasy Fet (1820–1892), Russian poet
 - Afanasy Grigoriev (1782–1868), Russian architect
 - Afanasy Nikitin (died 1472), Russian merchant and traveler
 - Afanasy Ordin-Nashchokin (1605–1680), Russian statesman
 - Afanasy Razmaritsyn (1844–1917), Russian-Ukrainian painter
 - Afanasy Seredin-Sabatin (1860–1921), Russian architect and journalist, first Western architect to live and work in the Korean Empire
 - Afanasy Shchapov (1830–1876), Russian historian
 
Fictional people:
- Afanasy Ivanovich Tovstogub, the main character of Nikolai Gogol's short story The Old World Landowners
 
The surname Afanasyev (Russian: Афана́сьев) is derived from the name. The surname Afonin (Russian: Афо́нин) is derived from Afonya, the short form of the name.
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