Big Z may refer to:
People
- Carlos Zambrano (born 1981), Venezuelan baseball pitcher in Major League Baseball
- Nikita Zadorov (born 1995), Russian ice hockey defenseman
- Zach Zenner (born 1991), NFL running back for the Detroit Lions
- Zbigniew Brzezinski (1928–2017), Polish-American political scientist
- Zdeno Chára (born 1977), Slovak ice hockey player
- Zelmo Beaty (1939–2013), basketball player in the National Basketball Association and American Basketball Association
- Zydrunas Ilgauskas (born 1975), Lithuanian basketball player in the National Basketball Association
- Žydrūnas Savickas (born 1975), Lithuanian strongman
Fictional characters
- Zangief, a character from the Street Fighter Series
- Zaphod Beeblebrox, fictional President of the Universe from the Hitchhiker's Guide
- Zapp Brannigan, fictional starship captain from Futurama
- Zeke "Big Z" Topanga, a fictional penguin from the 2007 film, Surf's Up
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