Charles Coffin may refer to:
- Charles Coffin (writer) (1676–1749), French writer, educator and Jansenist
- Charles A. Coffin (1844–1926), first President of General Electric corporation
- Charles Carleton Coffin (1823–1896), author of several historic manuscripts
- Charles D. Coffin (1805–1880), U.S. Representative from Ohio
- Charles Edward Coffin (1841–1912), U.S. Congressman from Maryland
- Charles L. Coffin, American inventor of arc welding process
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