Chatelain or Châtelain is a French surname. Notable people with the surname include:
- Christine Chatelain, Canadian film and television actress
 - Clara de Chatelain (1807–1876), English writer and composer
 - Danièle Chatelain, professor of French and writer
 - Hélène Châtelain, (1935–2020), French actress
 - Hubert Paul Chatelain (1917–?)
 - Jean Baptiste Claude Chatelain (1710–?), French engraver
 - Jeremy Chatelain (disambiguation), multiple people
 
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