Combe is a surname. It is similar to the surname Coombes. Notable people with the surname include:
- Alan Combe (born 1974), Scottish footballer
 - Andrew Combe (1797–1847), Scottish physiologist
 - Carmela Combe (1898–1984), Peruvian aviator
 - David Combe (1943–2019), Australian political figure and wine industry executive
 - George Combe (1788–1858), Scottish writer on phrenology and education
 - Harvey Christian Combe (1752–1818), English brewer and Lord Mayor of London
 - Ivan Combe (1911–2000), American inventor
 - John Frederick Boyce Combe (1895–1967), British Army officer before and during World War II
 - Martha Combe (1806–1893), British philanthropist
 - Peter Combe (born 1948), Australian musician
 - Reginaldus de Combe (fl. 1300–1301), English Member of Parliament
 - Rose Combe (1883–1932), French writer
 - Thomas Combe (1796–1872), British printer and philanthropist
 
See also
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