DFB may refer to:
- Deerfield Beach, Florida, a city
- Decafluorobutane, a fluorocarbon gas
- Dem Franchize Boyz, former hip hop group, Atlanta, Georgia
- Dfb, Köppen climate classification for Humid continental climate
- Distributed-feedback laser, a diffraction laser system
- Dublin Fire Brigade, Ireland
- Dysfunctional Family BBQ, an annual K-Rockathon event
- Furka Steam Railway, Dampfbahn Furka-Bergstrecke, Switzerland
- German Football Association, Deutscher Fußball-Bund or DFB, the national football governing body of Germany
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