Don't Let Go may refer to:

Film

• Don't Let Go (2002 film), an American independent feature film
• Don't Let Go (2019 film), an American supernatural thriller film

Literature

• Don't Let Go (French: Ne lâche pas ma main), a 2013 novel by Michel Bussi
• Don't Let Go, a 2017 novel by Harlan Coben

Music

• Don't Let Go (Ben Sidran album), 1974
• Don't Let Go (Jerry Garcia Band album), 2001
• Don't Let Go (Isaac Hayes album), 1979, or the title song
• Don't Let Go (George Duke album), 1978
• "Don't Let Go (Love)", a 1996 song by En Vogue
• "Don't Let Go" (David Sneddon song), 2003
• "Don't Let Go" (Jesse Stone song), 1958
• "Don't Let Go" (The Rasmus song)
• "Don't Let Go" (Wang Chung song), 1984
• "Don't Let Go", a song by Bryan Adams and Sarah McLachlan from the soundtrack for the film Spirit: Stallion of the Cimarron
• "Don't Let Go", a song by Deep Purple from Rapture of the Deep
• "Don't Let Go", a song by Loverboy from Wildside
• "Don't Let Go", a song by Weezer from The Green Album
• "Don't Let Go", a song by Yo Majesty from Futuristically Speaking...Never Be Afraid
• "Don't Let Go", a song by R. Kelly from the soundtrack for the film Daddy's Little Girls