Fenwick is a surname. Notable people with the surname include:
- Alf Fenwick (1891–1975), English footballer
 - Alistair Fenwick (born 1951), retired British auto racing driver
 - Benedict Joseph Fenwick (1782–1846), the second Roman Catholic Bishop of Boston
 - Bobby Fenwick (born 1946), retired Major League Baseball player
 - Charles Fenwick (1850–1918), British trade unionist and politician
 - Edward Fenwick (1768–1832), Bishop of Cincinnati, Ohio
 - Eliza Fenwick (1766–1840), English author
 - Ethel Gordon Fenwick (1857–1947), British nurse
 - Fairfax Fenwick (1852–1920), New Zealand cricketer
 - Sir George Fenwick (editor) (1847–1929), New Zealand newspaper proprietor and editor
 - Herbert Fenwick (1861–1934), New Zealand cricketer
 - Irene Fenwick (1887–1936), American stage and silent film actress
 - Isabella Fenwick (1783 – 1856), British amanuensis and writer of Fenwick Notes
 - Jean Fenwick (1907-1998), American actress born in Trinidad
 - Jim Fenwick (1934-2021), Australian photojournalist
 - Sir John Fenwick, 1st Baronet (c. 1570 – c. 1658), English landowner
 - Sir John Fenwick, 3rd Baronet (1645–1697), English conspirator
 - John Fenwick (Quaker) (1618–1683), founder of Salem, New Jersey
 - Sir Leonard Fenwick, chief executive in the National Health Service
 - Lila Fenwick (1932–2020), American lawyer, human rights advocate, and United Nations official
 - Mark Fenwick (born 1948), British businessman, chairman of Fenwick (department store) chain
 - Millicent Fenwick (1910–1992), American politician and diplomat
 - Paul Fenwick (born 1969), retired Canadian international association football player
 - Perry Fenwick (born 1962), British actor
 - Peter Fenwick (politician) (born 1944), Canadian politician
 - Peter Fenwick (neuropsychologist), neuropsychiatrist and neurophysiologist
 - Ralph Fenwick, shipping insurer and director of the New Zealand Company in 1825
 - Ray Fenwick, guitarist and session musician
 - Scott Fenwick (born 1990), English professional footballer
 - Steve Fenwick (born 1951), former Wales international rugby union and league player
 - Terry Fenwick (born 1959), former England international footballer
 
Fictional characters:
- Chris Fenwick, fictional character on the British television soap opera Hollyoaks
 - Doreen Fenwick, fictional character on the British soap opera Coronation Street
 - Sir George and Maude Fenwick, characters in The Woman in Green
 - Martin Fenwick, villain in the cartoon Sherlock Holmes in the 22nd Century
 - Inspector Fenwick of the Royal Canadian Mounted Police and his daughter Nell Fenwick, associates of the cartoon character Dudley Do-Right
 - Vernon Fenwick, Teenage Mutant Ninja Turtles
 
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