Francis Lewis (1713–1802) was a signer of the United States Declaration of Independence as a representative of New York.
Francis Lewis may also refer to:
- Francis Lewis (botanist) (1875–1955), English botanist
 - Francis Lewis High School, New York
 - Francis Lewis (MP) (c. 1692–1744), English politician
 - Francis Draper Lewis (1849–1930), Philadelphian lawyer, co-founded the law firm Morgan, Lewis, later Morgan, Lewis & Bockius
 - SS Francis Lewis on List of Liberty ships
 
See also
- Frances Moloney née Lewis, Irish socialite and nun
 - All pages with titles containing Francis Lewis
 - All pages with titles containing Francis Louis
 - Frank Lewis (disambiguation)
 
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