Francisco Santos may refer to:
- Francisco Dos Santos (born 1974), Brazilian footballer
- Francisco Santos (swimmer, born 1962), Angolan/Portuguese swimmer, artist and writer, also known as Xesko
- Francisco Santos (swimmer, born 1998), Portuguese_swimmer
- Francisco Santos (baseball) (born 1974), former Major League Baseball outfielder
- Francisco Santos (footballer) (born 1904), Portuguese footballer
- Francisco Santos Calderón (born 1961), Colombian politician and journalist
- Francisco Santos Leal (born 1968), Spanish mathematician
- Francisco Cabrera Santos (1946–2010), mayor of Valencia, Carabobo, Venezuela
- Francisco Santos, Piauí, a municipality in the state of Piauí, Brazil
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