Gargamel may refer to:
- Gargamel, the villain of the comic strip and animated TV series The Smurfs
- Gargamel!, an American rock band
- Gargamel, a reggae artist better known as Buju Banton
- Gargamelle, giantess and mother of Gargantua in Gargantua and Pantagruel
- Gargamelle, a bubble chamber particle detector at CERN, named for the giantess
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