Gioconda ("the joyful one") may refer to:
- Giaconda (pharmaceutical company), an Australian biotechnology company
 - Gioconda cafe, patronised by musicians such as David Bowie and Elton John
 - La Gioconda (play), tragedy by Gabriele d'Annunzio
 - La Gioconda (opera), an 1876 opera by Amilcare Ponchielli
 - Mona Lisa or La Gioconda, a painting by Leonardo da Vinci
 
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