Hoss is a nickname of:
- Bill "Hoss" Allen (1922–1997), American radio disc jockey
 - Hoss Ellington (1935–2014), American NASCAR driver and team owner
 - Hoss Hodgson (1886–1967), American football player and coach
 - Jeff Hostetler (born 1961), former National Football League quarterback
 - Waylon Jennings (1937–2002), American country music singer
 - Hoss Wright, American rock drummer
 - Eric "Hoss" Cartwright, one of the main characters on the TV series Bonanza
 
See also
- Old Hoss Radbourn (1854–1897), American professional baseball pitcher
 - Corey Harrison, aka "Big Hoss", from the History Channel's Pawn Stars
 
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