Mole is a surname. Notable people with the surname include:
- Charles Mole (1886–1962), British architect
 - Chris Mole (born 1958), UK Labour Member of Parliament
 - Fenton Mole (1925–2017), American baseball player
 - Jamie Mole (born 1988), English professional footballer
 - Louis-Mathieu Molé (1781–1855), French statesman
 - Miff Mole (1898–1961), American jazz trombonist and band leader
 - Matthew Mole (born 1991), South African singer, songwriter, and musician
 
Fictional characters:
- Adrian Mole, fictional diarist in a series of comic novels by Sue Townsend
 - Rosie Mole, Adrian's sister
 
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