O'Kelly is a surname. Notable people with the surname include:
- Aloysius O'Kelly (1853–1936), Irish painter, brother of James Joseph O'Kelly
 - Auguste O'Kelly (1829–1900), music publisher in Paris
 - Christopher O'Kelly (1895–1922), Canadian recipient of the Victoria Cross
 - Don O'Kelly (1924–1966), American actor
 - Edward Peter O'Kelly (1846–1914), Irish politician
 - Gabriel O'Kelly (died 1731), Irish clergyman
 - George O'Kelly (1831–1914), Franco-Irish pianist and composer
 - Henri O'Kelly (1859–1938), Franco-Irish composer, pianist and organist
 - James O'Kelly (1735–1826), American Methodist clergyman
 - James Joseph O'Kelly (1845–1916), Irish politician
 - John J. O'Kelly (1872–1957), Irish politician
 - Joseph O'Kelly (1828–1885), Franco-Irish composer and pianist
 - Malcolm O'Kelly (born 1974), Irish rugby player
 - Roger Demosthenes O'Kelly (1880–1962), African-American lawyer
 - Seán T. O'Kelly (1882–1966), Irish politician, second President of Ireland
 - Seumas O'Kelly (1881–1918), Irish writer
 
Fictional characters
- Michael the O'Kelly, hero of seven books by Manning O'Brine
 - One of the titular families in The Kellys and the O'Kellys, the second novel of Anthony Trollope
 
See also
- Albéric O'Kelly de Galway (1911–1980), Belgian chess grandmaster
 - Mary O'Kelly de Galway (1905-1999), Irish Belgian resistance operative
 
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