Okereke is a surname of Nigerian origin. Notable people with the surname include:
- Barbara Okereke (born c. 1990), Nigerian entrepreneur
 - Bobby Okereke (born 1996), American gridiron football player
 - Chioma Okereke, British-Nigerian author
 - David Okereke (born 1997), Nigerian footballer
 - Emeka Okereke (born 1980), Nigerian photographer and filmmaker
 - Kele Okereke (born 1981), English musician
 - Ndi Okereke-Onyiuke (born 1950), Nigerian financier and stockbroker
 - Stephanie Okereke Linus (born 1982), Nigerian actress and director
 - Tasha Okereke and Tracie Okereke (born 1995), Brazilian rapper duo
 
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