Omphale was a legendary queen of Lydia in Greek mythology.
Omphale may also refer to:
- Omphale (Gérôme sculpture), a sculpture of the queen by Jean-Léon Gérôme.
 - Omphale (horse) (1781–1799), a British Thoroughbred racehorse and broodmare.
 - Omphale (wasp), a genus of hymenoptera of the family Eulophidae.
 - Daedalium, an ancient city of Sicily, which was also known as Omphale.
 
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