RME may refer to:
Science and technology
- Rapeseed Methyl Ester, a form of biodiesel
 - Receptor-mediated endocytosis, a biological process
 - Rich Media Environment, an Open Mobile Alliance standard for broadcasting multimedia content
 - Reaction mass efficiency, a metric to rate chemical reactions
 - RME-6 or GAPVD1, a protein encoded by the GAPVD1 gene
 
Transport
- Ronsdorf-Müngstener Eisenbahn or Ronsdorf-Müngsten Railway, North Rhine-Westphalia, Germany; see Wuppertal-Ronsdorf station
 - IATA Airport Code for Griffiss International Airport in Rome, New York
 
Other uses
- River Music Experience, in Davenport, Iowa
 - ISO 639:rme, Angloromani language, spoken by the Romani people
 
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