São Bartolomeu (Portuguese for Saint Bartholomew) may refer to the following places:
in Portugal
- São Bartolomeu (Borba), a civil parish in the municipality of Borba
 - São Bartolomeu (Coimbra), a civil parish in the municipality of Coimbra
 - São Bartolomeu (Vila Viçosa), a civil parish in the municipality of Vila Viçosa
 - São Bartolomeu de Regatos, a civil parish in the municipality of Angra do Heroísmo, Azores
 - São Bartolomeu dos Galegos, a civil parish in the municipality of Lourinhã
 - São Bartolomeu de Messines, a civil parish in the municipality of Silves
 
in Brazil
- São Bartolomeu River, a river in Goiás state
 
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