S60 may refer to:

Automobiles

• S-60 (tractor), a Soviet tractor
• Toyota Crown (S60), a sedan
• Volvo S60, a compact executive car

Aviation

• Blériot-SPAD S.60, a French biplane fighter
• Kenmore Air Harbor, in Kenmore, Washington, United States
• Sikorsky S-60, a prototype American flying crane

Consumer electronics

• S60 (software platform), for mobile devices
• Canon PowerShot S60, a digital camera
• Cat S60, a mobile phone
• Pentax Optio S60, a digital camera

Rail and transit

• S60 (Long Island bus)
• S60 (RER Fribourg), a rail line in Fribourg, Switzerland
• Lugano–Ponte Tresa Railway, in Ticino, Switzerland
• S60, a line of the Stuttgart S-Bahn

Other uses

• AZP S-60, a Soviet anti-aircraft gun
• INS Sindhukesari (S60), a submarine of the Indian Navy
• S60: This material and its container must be disposed of as hazardous waste, a safety phrase
• S60-class submarine, of the Spanish Navy
• S60 Shangqiu–Dengfeng Expressway, in China
• S60, a postcode district Rotherham, England