Sack is a surname. Notable people with the surname include:
- August Friedrich Wilhelm Sack (1703–1786), German Reformed preacher and theologian
 - Simon Heinrich Sack (1723–1791), German Privy Councillor to Frederick II of Prussia
 - Friedrich Samuel Gottfried Sack (1738–1817), German Reformed theologian
 - Karl Heinrich Sack (1789–1875), German Protestant theologian and university professor
 - Karl Sack (1896–1946), German jurist and member of the anti-Nazi resistance movement in World War II
 - Erna Sack (1898–1972), German opera singer (soprano)
 - Jack Sack (1902–1980), American football player and coach
 - John Sack (1930–2004), American journalist
 - Sibylle Kemmler-Sack (1934–1999), German chemist
 - Robert D. Sack (born 1939), American judge
 - Robert L. Sack (born 1942), American physician
 - Steve Sack (born 1953), American editorial cartoonist
 - Brian Sack (born 1968), American actor and humorist
 - Peter Sack (born 1979), German shot putter
 
Fictional characters:
- Johnny Sack, character in The Sopranos
 
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