Santa Sofia may refer to:
- Counts di Santa Sofia, a title used in a family on the island of Malta
 - Santa Sofia (grape), an Italian wine grape that is also known as Fiano
 
Places
- Santa Sofia d'Epiro, an Arberesh town and comune in Cosenza, Italy
 - Santa Sofia, Emilia–Romagna, a comune in the Province of Forlì-Cesena in Emilia–Romagna, Italy
 - Santa Sofía, Boyacá, a town and municipality in Boyacá, Colombia
 
Architecture
- Santa Sofia a Via Boccea, a church in Rome, Italy, built in the 1960s
 - Santa Sofia (Benevento) (8th century), a church in Benevento
 - Santa Sofia, Naples (1487), a church in Naples
 - Santa Sofia Church (Padua) (10th century), a church in Padua
 - Santa Sofia a Via Boccea (1968), a church in Rome
 - Santa Sofia (Venice) (11th century), a church in Venice
 - Palazzo Santa Sofia, a palace in Mdina, Malta
 
See also
- Hagia Sophia (disambiguation)
 - Santa Sophia (disambiguation)
 - Sofia (disambiguation)
 
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