Simonetta is an Italian surname and female given. Notable people with the name include:
Given name
- Simonetta Colonna di Cesarò (1922-2011), Italian duchess and fashion designer
 - Simonetta Moro, Italian fine artist
 - Simonetta Puccini (1929–2017)
 - Simonetta Greggio, Italian novelist who writes in French
 - Simonetta Paloscia, Italian engineer
 - Simonetta Stefanelli (born 1954), Italian actress, born in Rome, Italy
 - Simonetta Vespucci (1453–1476), the wife of the Italian nobleman Marco Vespucci of Florence
 - Simonetta Di Pippo, Italian astrophysicist
 - Simonetta Lein, American model
 - Simonetta Sommaruga, Swiss politician
 
Surname
- Cicco Simonetta (1410–1480), Italian secretary, statesman and cryptographer
 - Ada Sacchi Simonetta (1874–1944), Italian librarian
 - Umberto Simonetta (1926–1998), Italian playwright, writer and lyricist
 - Francesco Simonetta, Roman Catholic prelate
 
See also
- 29706 Simonetta, a main-belt asteroid
 
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