Vopiscus may refer to:
- Vopiscus (praenomen), a Latin praenomen, or personal name
 - Vopiscus Julius Iulus, a Roman consul in 473 BC
 - Gaius Julius Caesar Strabo Vopiscus (c. 130 — 87 BC), an orator and tragedian
 - Marcus Manilius Vopiscus, a Roman consul in AD 60
 - Lucius Pompeius Vopiscus, a Roman consul in AD 69
 - Publius Manilius Vopiscus Vicinillianus, a Roman consul in AD 114
 - Flavius Vopiscus, one of the 4th century authors of the Historia Augusta
 
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