Wiles is a surname. Notable people with the surname include:
- Adam Wiles (born 1984), real name of Scottish singer, songwriter, DJ, and producer Calvin Harris
- Andrew Wiles, British mathematician who proved Fermat's Last Theorem
- Archie Wiles, cricketer from Trinidad
- Billy Wiles, American wrestler
- Collin Wiles, American baseball player
- Evangeline Wiles, Nigerian entrepreneur
- Irving Ramsey Wiles, United States artist
- Jason Wiles, actor, director and producer
- John Wiles, British television producer
- Lemuel M. Wiles (1826–1905), American landscape painter.
- Margaret Jones Wiles (1911-2000) American composer, conductor, and teacher
- Maurice Wiles, British theologian, father of Andrew Wiles
- Mary Kate Wiles, American film, TV and YouTube actor
- Michele Wiles, principal dancer at American Ballet Theatre
- Simon Wiles, English footballer
- Siouxsie Wiles, microbiologist and science communicator
See also
- 9999 Wiles, an asteroid
- Cape Wiles, a headland in South Australia
- Wile (disambiguation)
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