William McPherson or Macpherson may refer to:
- William Macpherson (bureaucrat) (1784–1866), Clerk of the Legislative Council of New South Wales
 - William Macpherson (British Army officer) (1858–1927), colonel-commandant and author
 - William Macpherson (judge) (1926–2021), judge of the High Court of England and Wales and chair of the enquiry into the murder of Stephen Lawrence
 - William MacPherson (priest) (1901–1978), Anglican Dean of Lichfield
 - William Macpherson (cricketer), English cricketer
 - William McPherson (university president) (1864–1951), president of Ohio State University
 - William Murray McPherson (1865–1932), Australian philanthropist and politician
 - William McPherson Allen (1900–1985), American aircraft businessman
 - William McPherson (writer) (1933–2017), 1977 winner of the Pulitzer Prize for Criticism
 - William David McPherson (1863–1929), Ontario barrister and political figure
 
See also
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