Qualification round I

The top two ranked sides from each group advance.^[2]

Group A

• 30 September–3 October 2021, Šibenik, Croatia.

Pos	Team	Pld	W	D	L	GF	GA	GD	Pts	Qualification		PAL	SOL	STA	SHT	CAR
1	Telimar Palermo	4	4	0	0	75	27	+48	12	Round II		—	—	—	—	33–1
2	Solaris Šibenik	4	3	0	1	57	24	+33	9			9–10	—	13–6	—	23–6
3	St Andreu	4	2	0	2	50	39	+11	6			13–14	—	—	17–7	—
4	Shturm 2002 Ruza	4	1	0	3	24	55	−31	3			4–18	2–12	—	—	—
5	Carouge Natation	4	0	0	4	20	81	−61	0			—	—	5–14	8–11	—

Source: LEN

Group B

• 1–3 October 2021, Syracuse, Sicily, Italy.

Pos	Team	Pld	W	D	L	GF	GA	GD	Pts	Qualification		CCO	STR	GSP	LUD
1	CC Ortigia	3	3	0	0	40	23	+17	9	Round II		—	13–7	11–8	16–8
2	Team Strasbourg	3	2	0	1	31	28	+3	6			—	—	—	16–8
3	GS Peristeri	3	1	0	2	26	25	+1	3			—	7–8	—	—
4	Ludwigsburg 08	3	0	0	3	22	43	−21	0			—	—	6–11	—

Source: LEN

Group C

• 30 September–3 October 2021, Utrecht, Netherlands.

Pos	Team	Pld	W	D	L	GF	GA	GD	Pts	Qualification		VSC	ŠAB	UTR	ENT	DUI
1	Vasas Budapest	4	4	0	0	50	22	+28	12	Round II		—	9–5	—	11–7	16–3
2	Šabac	4	1	2	1	32	34	−2	5			—	—	—	6–6	—
3	UZSC Utrecht	4	1	1	2	34	47	−13	4[lower-alpha 1]			7–14	8–8	—	9–8	10–17
4	EN Tourcoing	4	1	1	2	34	37	−3	4[lower-alpha 1]			—	—	—	—	13–11
5	ASC Duisburg	4	1	0	3	42	52	−10	3			—	11–13	—	—	—

Source: LEN
Notes:

1. 1 2 UZSC Utrecht 9–8 EN Tourcoing

Group D

• 1–3 October 2021, Novi Sad, Serbia.

Pos	Team	Pld	W	D	L	GF	GA	GD	Pts	Qualification		ZUG	CNS	AEK	VOJ
1	BVSC Zugló	3	3	0	0	39	26	+13	9	Round II		—	—	13–6	—
2	Astralpool Sabadell	3	2	0	1	31	25	+6	6			9–12	—	—	—
3	AEK Athens	3	0	1	2	23	32	−9	1			—	8–10	—	—
4	Vojvodina Novi Sad	3	0	1	2	25	35	−10	1			11–14	5–12	9–9	—

Source: LEN

Qualification round II

The top two ranked sides from each group advance.^[3][4]

Group E

• 8–10 October 2021, Palermo, Italy.

Pos	Team	Pld	W	D	L	GF	GA	GD	Pts	Qualification		PAL	ZUG	ŠAB	STR
1	Telimar Palermo	3	2	1	0	45	35	+10	7	Quarterfinals		—	17–17	—	14–10
2	BVSC Zugló	3	2	1	0	39	34	+5	7			—	—	—	—
3	Šabac	3	0	1	2	25	32	−7	1			8–14	7–8	—	10–10
4	Team Strasbourg	3	0	1	2	30	38	−8	1			—	10–14	—	—

Source: LEN

Group F

• 8–10 October 2021, Budapest, Hungary.

Pos	Team	Pld	W	D	L	GF	GA	GD	Pts	Qualification		CNS	CCO	VSC	SOL
1	Astralpool Sabadell	3	2	0	1	25	23	+2	6[lower-alpha 1]	Quarterfinals		—	—	—	10–9
2	CC Ortigia	3	2	0	1	28	24	+4	6[lower-alpha 1]			10–9	—	—	—
3	Vasas Budapest	3	2	0	1	24	18	+6	6[lower-alpha 1]			4–6	8–7	—	12–5
4	Solaris Šibenik	3	0	0	3	21	33	−12	0			—	7–11	—	—

Source: LEN
Notes:

1. 1 2 3 Astralpool Sabadell 2 Pts, +1 GD; CC Ortigia 2 Pts, 0 GD; Vasas Budapest 2 Pts, −1 GD

Bracket

	Quarter-finals						Semi-finals						Final
	HAVK Mladost	7	7	24
	Telimar Palermo	11	16	27
							Telimar Palermo	10 (w/o)	6	16
							Ortigia	0	7	7
	Ortigia	9	15	24
	Szolnok	4	10	14
													Telimar Palermo	9	5	14
													Sabadell	7	11	18
	Barcelona	6	12	18
	BVSC-Zugló	6	9	15
							Barcelona	10	9	19
							Sabadell	12	8	20
	Sabadell (p)	13	10	23 (16)
	Savona	13	10	23 (15)

Quarter-finals

The four best teams from the Euro Cup qualifications and the four losing sides of the Champions League Qualification Round III have been paired in the quarter-finals.^[5]

Team 1	Agg.Tooltip Aggregate score	Team 2	1st leg	2nd leg
Sabadell	23–23 (16–15 p)	Savona	13–13	10–10
Ortigia	24–14	Szolnok	9–4	15–10
HAVK Mladost	14–27	Telimar Palermo	7–11	7–16
Barcelona	18–15	BVSC-Zugló	6–6	12–9

Semi-finals

Team 1	Agg.Tooltip Aggregate score	Team 2	1st leg	2nd leg
CN Barcelona	19–20	Sabadell	10–12	9–8
Telimar Palermo	16–7	Ortigia	10–0w/o	6–7

Finals

Team 1	Agg.Tooltip Aggregate score	Team 2	1st leg	2nd leg
Telimar Palermo	14–18	Sabadell	9–7	5–11