Oxantel

Oxantel
Clinical data
ATC code	P02CC02 (WHO) QP52AF03 (WHO);
Identifiers
	IUPAC name 3-[(E)-2-(1-Methyl-5,6-dihydro-4H-pyrimidin-2-yl)ethenyl]phenol;
CAS Number	36531-26-7 ;
PubChem CID	5281087;
ChemSpider	4444540 ;
UNII	94AJJ30D9E;
KEGG	D00806 ;
Chemical and physical data
Formula	C13H16N2O
Molar mass	216.284 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN1CCCN=C1/C=C/C2=CC(=CC=C2)O;
	InChI InChI=1S/C13H16N2O/c1-15-9-3-8-14-13(15)7-6-11-4-2-5-12(16)10-11/h2,4-7,10,16H,3,8-9H2,1H3/b7-6+ ; Key:VRYKTHBAWRESFI-VOTSOKGWSA-N ;
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Oxantel is an anthelmintic. It has typically been used in human and animal medicine as a treatment for intestinal worms.^[1]

Oxantel has been shown to inhibit fumarate reductase in some pathogenic bacteria.^[2]

References

↑ Palmeirim MS, Specht S, Scandale I, Gander-Meisterernst I, Chabicovsky M, Keiser J (June 2021). "Preclinical and Clinical Characteristics of the Trichuricidal Drug Oxantel Pamoate and Clinical Development Plans: A Review". Drugs. 81 (8): 907–921. doi:10.1007/s40265-021-01505-1. PMC 8144136. PMID 33929716.
↑ Dashper S, O'Brien-Simpson N, Liu SW, Paolini R, Mitchell H, Walsh K, D'Cruze T, Hoffmann B, Catmull D, Zhu Y, Reynolds E (2014). "Oxantel disrupts polymicrobial biofilm development of periodontal pathogens". Antimicrobial Agents and Chemotherapy. 58 (1): 378–85. doi:10.1128/AAC.01375-13. PMC 3910723. PMID 24165189.

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